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PI-103 hydrochloride
CAS No. 371935-79-4
PI-103 hydrochloride ( PI 103 hydrochloride;PI103 hydrochloride )
Catalog No. M14283 CAS No. 371935-79-4
A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePI-103 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.
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DescriptionA potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively; also inhibits TORC1 (>80% inhibition at 0.5 uM) and DNA-PK (IC50=14 nM), 15- to 20-fold less activity against class II PI3K C2β (IC50=43 nM), >1,300-fold selectivity over the class III PI3K Vsp34; potently inhibits proliferation and invasion of a wide variety of human cancer cells in vitro; shows activity in cancer xenograft models.
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SynonymsPI 103 hydrochloride;PI103 hydrochloride
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number371935-79-4
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Formula Weight384.82
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Molecular FormulaC19H17ClN4O3
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Purity>98% (HPLC)
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SolubilityDMSO: 4.1 mg/mL; H2O: < 4 mg/mL
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SMILESC1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O.Cl
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Chemical NamePhenol, 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fan QW, et al. Cancer Cell. 2006 May;9(5):341-9.
2. Raynaud FI, et al. Cancer Res. 2007 Jun 15;67(12):5840-50.
3. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.
4. Kojima K, et al. Leukemia. 2008 Sep;22(9):1728-36.
2. Raynaud FI, et al. Cancer Res. 2007 Jun 15;67(12):5840-50.
3. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.
4. Kojima K, et al. Leukemia. 2008 Sep;22(9):1728-36.
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