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PI-103 hydrochloride

CAS No. 371935-79-4

PI-103 hydrochloride ( PI 103 hydrochloride;PI103 hydrochloride )

Catalog No. M14283 CAS No. 371935-79-4

A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PI-103 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.
  • Description
    A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively; also inhibits TORC1 (>80% inhibition at 0.5 uM) and DNA-PK (IC50=14 nM), 15- to 20-fold less activity against class II PI3K C2β (IC50=43 nM), >1,300-fold selectivity over the class III PI3K Vsp34; potently inhibits proliferation and invasion of a wide variety of human cancer cells in vitro; shows activity in cancer xenograft models.
  • Synonyms
    PI 103 hydrochloride;PI103 hydrochloride
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3K
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    371935-79-4
  • Formula Weight
    384.82
  • Molecular Formula
    C19H17ClN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 4.1 mg/mL; H2O: < 4 mg/mL
  • SMILES
    C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O.Cl
  • Chemical Name
    Phenol, 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fan QW, et al. Cancer Cell. 2006 May;9(5):341-9.
2. Raynaud FI, et al. Cancer Res. 2007 Jun 15;67(12):5840-50.
3. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.
4. Kojima K, et al. Leukemia. 2008 Sep;22(9):1728-36.
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